Patients with sugar intolerance should not take this medicine.

The use of minocycline during tooth development in children under the age of 12 years may cause permanent discoloration.

Minocycline should be used with caution in patients with renal impairment or hepatic dysfunction or myasthenia gravis.

Rare cases of auto-immune hepatotoxicity and isolated cases of systemic lupus erythematosus have been reported.

Minocycline may cause hyperpigmentation at various body sites.

Patients should be warned that minocycline may reduce the efficacy of combined oral contraceptives if diarrhoea or breakthrough bleeding occurs.