Oral
Susceptible infections
Adult: Initially, 200 mg followed by 100 mg every 12 hr.

Child: >8 yr: Initially, 4 mg/kg followed by 2 mg/kg every 12 hr.
 

Oral
Acne
Adult: 50 mg 2 times a day or 100 mg once daily.

Child: ≥12 yr: 45-59 kg: 45 mg once daily; 60-90 kg: 90 mg once daily; 91-136 kg: 135 mg once daily.

Oral
As part of multidrug therapy for multibacillary leprosy
Adult: Patients intolerant to rifampicin: Regimen includes clofazimine (50 mg daily), ofloxacin (400 mg daily), and minocycline (100 mg daily) for 6 mth, followed by a regimen of clofazimine (50 mg daily) and minocycline (100 mg daily) for at least an additional 18 mth. Patients intolerant to clofazimine: Once-monthly multiple-drug regimen includes rifampicin (600 mg), ofloxacin (400 mg) and minocycline (100 mg) for 24 mth.
 

Oral
Asymptomatic meningococcal carriers
Adult: 100 mg 2 times a day for 5 days followed by a course of rifampicin.
 

Oral
As part of multidrug therapy for single-lesion paucibacillary leprosy
Adult: Regimen includes a single 600-mg dose of rifampicin, a single 400-mg dose of ofloxacin, and a single 100-mg dose of minocycline.
Child: 5-14 yr: Regimen includes a single 300-mg dose of rifampicin, a single 200-mg dose of ofloxacin, and a single 50-mg dose of minocycline;

Oral
Nongonococcal urethritis
Adult: 100 mg every 12 hr for at least 7 days.

Oral
Uncomplicated gonorrhoea
Adult: Initially, 200 mg, followed by 100 mg every 12 hr for a min of 4 days

Oral
Uncomplicated urethral gonorrhoea in men
Adult: 100 mg every 12 hr for 5 days.
 

Oral
Mycobacterium marinum infections
Adult: 100 mg every 12 hr for 6-8 week. Cutaneous infection: 100 mg 2 times a day for at least 3 month
 

Oral
Nocardiosis
Adult: 200 mg initially, followed by 100 mg every 12 hr in conjunction with a sulfonamide for 12-18 month.
 

Oral
Rheumatoid arthritis
Adult: 100 mg 2 times a day.
 

Oral
Syphilis
Adult: 200 mg initially, followed by 100 mg every 12 hr for 10-15 days.
 

Oral
Cholera
Adult: Initially, 200 mg followed by 100 mg every 12 hr for 48-72 hr in conjunction with fluid and electrolyte replacement.
 

Intravenous
Susceptible infections
Adult: Initially, 200 mg followed by 100 mg every 12 hr by slow intravenous infusion.
 

Intrapleural
As sclerosing agent to control pleural effusions associated with metastatic tumours
Adult: Dilute 300 mg in 40-50 ml of 0.9% sodium chloride injection and instil into the pleural space through a thoracostomy tube, followed by clamping of the tube and subsequent removal of the fluid.
 

Topical/Cutaneous
Periodontitis
Adult: As a modified-release subgingival gel: Insert into the periodontal pocket as an adjunct to scaling and root planing. Total number of cartridges to be used depends on the size, shape and number of pockets being treated.
 

Topical/Cutaneous
Periodontal infections
Adult: Apply 2% gel to affected area.