Oral

Replacement therapy in adrenocortical insufficiency
Adult: 20-30 mg daily in 2 divided doses.
Child: 400-800 microgram/kg/day, in 2-3 divided doses. 
 

Intravenous

As supplement in adrenal insufficiency during minor surgery under general anaesthesia
Adult: In patients taking >10 mg of prednisolone or its equivalent by mouth daily. 25-50 mg at induction

As supplement in adrenal insufficiency during moderate or major surgery
Adult: In patients taking >10 mg of prednisolone or its equivalent by mouth daily. Usual oral corticosteroid dose on the morning of the surgery followed by 25-50 mg at induction, then similar doses of hydrocortisone thrice daily for 24 hr after moderate surgery or 48-72 hr after major surgery

Acute adrenocortical insufficiency
Adult: 100-500 mg 3-4 times/24 hr

Child: <1 yr: 25 mg; 1-5 yr: 50 mg; 6-12 yr: 100 mg.

Local Injection

Soft tissue inflammation
Adult: 100-200 mg as local injection. 
 

Intra-articular

Joint inflammations
Adult: 5-50 mg depending on size of affected joint. 
 

Topical / Cutaneous

Corticosteroid-responsive dermatoses
Adult: Apply a 0.1-2.5% cream/ointment/lotion onto affected area.