Oral

Prostate cancer
Adult: 10 mg three times a day for at least 3 month.
 

Moderate to severe vasomotor symptoms associated with menopause
Adult: 1-2 mg/day adjusted as necessary; admin can be cyclical (3 week on, 1 week off)

Prophylaxis of osteoporosis in postmenopausal women
Adult: 0.5 mg/day in cyclic regimen (23 days on and 5 days off). 
 

Hypogonadism
Adult: 1-2 mg/day in a cyclic regimen for 3 week on drug, followed by 1 wk drug-free.
 

Intramuscular

Prostate cancer
Adult:  ≥30 mg every 1-2 week.
 

Moderate to severe vasomotor symptoms associated with menopause
Adult:  1-5 mg every 3-4 week.

Hypogonadism
Adult:  10-20 mg every 4 week.

Transdermal

Moderate to severe vasomotor symptoms associated with menopause
Adult:  0.025 mg/day once weekly

Prophylaxis of osteoporosis in postmenopausal women
Adult: 14 microgram/day once or twice weekly.

Vaginal

Vulvular and vaginal atrophy
Adult:  2-4 g/day of vaginal cream intravaginally for 2 week

Postmenopausal vaginal atrophy
Adult:  vaginal ring containing 2 mg of estradiol and keep in place for 90 days.
 

Urogenital symptoms
Adult: vaginal ring containing 2 mg of estradiol and keep in place for 90 days.

Atrophic vaginitis
Adult: Initial: Insert 20 microgram once daily for 2 week.