Some loss of effects of Alprazolam may develop after repeated use for a few weeks. Use of Alprazolam may lead to the development dependence to the drug. Once the drug dependence has developed, immediate termination of treatment can accompanied by headaches, muscle pain, extreme anxiety, tension, numbness and tingling of the extremities, hypersensitivity to light, restlessness, confusion and irritability hallucinations or epileptic seizures.

The duration of treatment should be as short as possible depending on the indication, but should not exceed eight to twelve weeks including tapering off process. Alprazolam should not be given to children without careful assessment of the need. The elderly should be given a reduced dose. A lower dose is also recommended for patients with chronic respiratory insufficiency and in patient with impaired kidney or liver function. Alprazolam should not be used alone to treat depression of anxiety associated with depression. Alprazolam should be used with caution in patients with a history of alcohol or drug abuse.